Reversible electroporation is an advanced medical technology currently used primarily as part of a combined treatment called Electrochemotherapy for treating cancerous tumors in the abdominal cavity. Unlike other methods that destroy the tumor using heat or cold, or unlike Irreversible Electroporation (NanoKnife) which destroys the cell electrically, the goal here is different.

The method uses short, precise electrical pulses to temporarily and reversibly create tiny "holes" in the membrane of tumor cells. This momentary opening of the cell membrane allows chemotherapy drugs, injected into the bloodstream or directly into the tumor, to penetrate the cancer cells with efficiency thousands of times higher than standard chemotherapy treatment. After the electrical current stops, the pores close, trapping the drug inside the cancer cell and destroying it from within. The treatment is intended for patients with abdominal tumors, such as liver metastases or pancreatic tumors, which do not respond well to standard treatments or whose location does not allow for surgery.

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The procedure is performed in a dedicated interventional radiology treatment room, usually under general anesthesia, as the electrical pulses can cause muscle contractions.

The specialist physician inserts electrodes (thin needles) through the skin into the tumor area in the abdomen, under the guidance of imaging means such as ultrasound or CT to ensure maximum precision. Simultaneously, the patient is given a chemotherapy drug at an adjusted dose. At the appropriate moment, the device delivers the series of electrical pulses between the needles, an action that lasts only a few minutes. The combination of electricity and chemotherapy allows for highly focused and effective treatment of the tumor itself, using relatively low drug doses, thereby reducing the systemic side effects of chemotherapy.